Most mortality occurred within a week of treatment. Hatching success was significantly reduced in mallards treated at 3 and 10 times the maximum field application, with a calculated approximate LD50 of 1.9 times the maximum field application. As part of an evaluation of the potential effects of GB-1111 on birds, fertile eggs of mallards (Anas platyrhynchos) and bobwhite (Colinus virginianus) were incubated in the laboratory, and treated on day 4 of incubation with external applications equivalent to either 0, 1/3, 1, 3 or 10 times the maximum rate (X) of 47 l/ha (5 gal/A) of field application of GB-1111. Golden Bear Oil (GB-1111 legal trade name for GB-1313) is a petroleum distillate used in the United States and other countries as a mosquito larvicide. We would like to alert on the importance of testing for gasoline, and in general for volatile hydrocarbons, in work-related sudden deaths involving inhalation of hydrocarbon vapors and/or exhaust fumes. Based upon the toxicological data along with the autopsy findings, the cause of death was determined to be gasoline poisoning and the manner of death was accidental. Disposition of gasoline in different tissues was as follows: heart blood, 35.7 mg/L urine, not detected vitreous humor, 1.9 mg/L liver, 194.7 mg/kg lung, 147.6 mg/kg and gastric content, 116,6 mg/L (2.7 mg total). The toxicological screening and quantitation of gasoline was performed by means of gas chromatography with flame ionization detector and confirmation was performed using gas chromatography-mass spectrometry. The internal examination showed a strong odor of gasoline, specially detected in the respiratory tract. Extensive blistering and peeling of skin were observed on the skin of the face, neck, anterior chest, upper and lower extremities, and back. He died suddenly after inhaling gasoline vapors from an accidental leak.
A 51 year-old Caucasian healthy man without significant medical history was supervising the repairs of the telephone lines in a manhole near to a gas station. The importance of this petroleum distillate detection and its quantitative toxicological significance is discussed using a validated analytical method.
This work describes a sudden occupational fatality involving gasoline. Gasoline is a complex and highly variable mixture of aliphatic and aromatic hydrocarbons that can lead to cardiac arrhythmias due to sensitization of the myocardium to catecholamines or acts as a simple asphyxiant if the vapors displace sufficient oxygen from the breathing atmosphere. The investigation of uncertain fatalities requires accurate determination of the cause of death, with assessment of all factors that may have contributed to it.
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